A Possible Variant of PANDAS: Dystonic Subtype

PANDAS: a new disease?

OBJECTIVE To establish the diagnostic criteria for PANDAS and to analyze the existing evidence regarding its etiopathogenesis, treatment and prophylaxis. SOURCES Review of the scientific literature through a MEDLINE search carried out between 1989 and 2006. SUMMARY OF THE FINDINGS The diagnostic criteria for PANDAS were established nearly 10 years ago, but a lot of controversy still exists ...

Treating PANDAS

Clues to a possible new variant of thyroid hormone resistance.

Patients with thyroid hormone resistance, first described by Refetoff et al. in 1967 (1), usually present with goitre, elevated thyroid hormone levels and an inappropriately normal or elevated thyrotrophin (TSH) level (reviewed in 2, 3). Clinical effects of thyroid hormone resistance can include variable features of hypoand hyperthyroidism such as tachycardia, attention deficit/hyperactivity di...

Possible underascertainment of variant Creutzfeldt-Jakob disease: a systematic study.

OBJECTIVES To predict the size of the vCJD epidemic it is important to know whether the description of cases of vCJD in 1996 represent the first cases of a new disease entity or whether detection was due to increased surveillance of CJD in humans. Detection of earlier cases would suggest a shorter incubation period and might lead to predictions of epidemic size being revised. METHODS All cert...

Acute Dystonic Reaction Associated with Cefuroxime Axetil in a Child Running Title: Acute Dystonic Reaction

Dystonia is an extrapyramidal motor function disorder characterized by intermittent spasmodic or sustained involuntary muscle contractions of the face, neck, trunk, pelvis and extremities causing repetitive movements and postural abnormalities [1,2]. The abnormal posture may induce significant anxiety and distress for the patient and relatives. In adults, the head and neck muscles are the most ...